Antimicrobial peptide
Effective antimicrobial peptides for a new generation of farming
- Cyclic lipopeptide L20RX83
- Gram-positive bacteria
- 0-day withdrawal
Antimicrobial solutions that work.
Lipotide is a new generation cyclic lipopeptide (L20RX83) that has shown strong antibacterial activity against a wide range of gram-positive bacteria and is also effective in controlling coccidiosis in poultry. It is effective against bacteria such as Clostridium perfringens, Staphylococcus spp., Streptococcus spp. and Enterococcus spp.
Key benefits of Lipotide
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Heat-stable
Antimicrobial activity remains >90% at 150°C for 30 minutes.
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0-day withdrawal
No withdrawal period for meat, egg or byproducts.
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Acid-stable
Not affected by acidic pH or contact with acidifiers.
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In vivo and in vitro effective
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Sustainable
Production and usage does not damage the environment.
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Low resistance development
Bacteria is slow to develop resistance against Lipotide.
Antimicrobial peptides: bacterial control without antibiotics
Alternative Antibiotic Growth Promoter (AAGP)
Lipotide belongs to the class of cyclic lipopeptides, which are known for their strong antibacterial activity. Lipotide disrupts the cell wall of gram-positive bacteria, causing the bacteria to lose their structural integrity and leads to death. Specifically, Lipotide binds to lipid II, a key precursor in the synthesis of the bacterial cell wall, and prevents its incorporation into the cell wall.
Lipotide attacks the cell wall
Lipotide binds to lipid II, preventing cell wall formation
Lipotide, a new solution for pathogen control
Inhibition zones on agar plates. Each numbered well holds Lipotide at the concentration listed; a wider clear zone means stronger inhibition.
Clostridium perfringens type A
- Well 1: Lipotide at 1000 ppm
- Well 2: Lipotide at 900 ppm
- Well 3: Lipotide at 800 ppm
- Well 4: Lipotide at 700 ppm
- Well 5: Lipotide at 600 ppm
- Well 6: Lipotide at 500 ppm
Staphylococcus aureus ATCC 33591
- Well 1: Lipotide at 1000 ppm
- Well 2: Lipotide at 800 ppm
- Well 3: Lipotide at 600 ppm
- Well 4: Lipotide at 400 ppm
Usage and administration
Indicative dosage and application.
| Stage | Prevention | Treatment |
|---|---|---|
| Broiler | ||
| Broiler starter | 100g per tonne feed | 150g per tonne feed |
| Broiler grower/finisher | 150g per tonne feed | 200g per tonne feed |
| Pullet – layer/breeder | ||
| Pullet (1–14 weeks) | 100g per tonne feed | 200g per tonne feed |
| Pullet (14–18 weeks) | 150g per tonne feed | 200g per tonne feed |
| Pullet (> 18 weeks) | 150g per tonne feed | 200g per tonne feed |
| Nursery pigs | ||
| Week (1–14 weeks) | 100g per tonne feed | 200g per tonne feed |
| > 4 weeks | 100g per tonne feed | 200g per tonne feed |
| Grower pigs | ||
| < 6 weeks after weaning | 200g per tonne feed | 300g per tonne feed |
| > 6 weeks after weaning | 200g per tonne feed | 300g per tonne feed |
Field trial results
The field trial conducted on Lipotide was carried out in Myanmar by the University of Veterinary Science, Yezin between February–June 2022. The trial involved 6 closed houses, with 2 houses allocated per group and 8,000 ISA White pullets per house. The three groups were: treated with Lipotide, treated with lincomycin hydrochloride, and untreated. Significant results were observed in the Lipotide-treated group, which showed a difference of 33% in mortality rates compared to the untreated group and similar results when compared to the group treated with lincomycin hydrochloride.
These results demonstrate Lipotide’s potential as a beneficial solution for the poultry industry in terms of enhanced health and productivity. Its antimicrobial properties offer a novel approach to combat bacterial infections and improve overall chicken well-being in the poultry sector.
The successful trial in Myanmar, conducted in a large-scale setting with 6 closed houses and three distinct groups, underscores the potential of Lipotide as a practical and effective solution for real-world poultry farming.
Mortality (%)
Morbidity (%)
The real future of antimicrobials.
For supply and technical data on Lipotide in your market, contact our team. The full brochure (FV7.24) is available to download.